Thermodynamic non-equilibrium is a defining feature of living systems on all levels of organization. Cells and tissues are built of “active matter”, dynamic materials with built-in force generators. Such materials self-organize in biological systems into well-ordered dynamic steady states, sustained by the dissipation of metabolic energy. The materials show striking collective phenomena on a mesoscopic scale, reminiscent of second order phase transitions and criticality.
We use advanced light microscopy as well as microscopic motion and force-sensing techniques to characterize the complex mechanical properties of and the motion and stress patterns in biological active matter, in particular the actin cortex, all the way from reconstituted model systems to cells and tissues. We quantitate thermodynamic non-equilibrium using fundamental concepts of statistical physics such as the fluctuation-dissipation theorem and the principle of detailed balance.
Professor Christoph Schmidt obtained a Diplom and a Dr. Rer. Nat. at the Technical University of Munich in Germany. He did postdoctoral stays at Munich, Harvard, and Cambridge. He was in the Physics faculty at the University of Michigan, and became a full professor of Physics at the Vrije University in Amsterdam. Since 2006, he has been a full professor of Physics at the Georg-August University in Gottingen. His interest is on motor proteins, the physical principles of biological force generation, transport processes, collective machines, and mitotic spindle. His research includes the use of optical tweezers, and single-molecule fluorescence. Prof. Schmidt is an elected member of the Gottingen Academy of Sciences and Humanities, and a Fellow of the American Physical Society.