Oliver Beckstein

Assistant Professor
Faculty
TEMPE Campus
Mailcode
1504
Asst Professor
Faculty
TEMPE Campus
Mailcode
1504
PHY - Asst Professor
Faculty
TEMPE Campus
Mailcode
1504
Asst Professor
Faculty
TEMPE Campus
Mailcode
1504

Biography

Oliver Beckstein, Dipl.-Phys., DPhil, leads a computational research group in the Center for Biological Physics and in the Department of Physics at ASU.

He obtained his undergraduate degree (Diplom Physik) from the Department of Physics at the Universität Erlangen-Nürnberg, Germany and his doctoral degree (DPhil) from the Department of Biochemistry at the University of Oxford, UK. He held a Junior Research Fellowship at Merton College, Oxford and worked as a postdoctoral researcher with Tom Woolf at Johns Hopkins University and Mark Sansom in Oxford.

Dr. Beckstein's research group uses and develops computational methods to better understand the molecular mechanisms of biological processes. A special focus is on the quantitative prediction of the function and activity of proteins from the knowledge of their structures alone. The group has special expertise in transmembrane transport processess catalyzed by membrane proteins such as secondary active transporters and ion channels. The group contributes to the fields of structural biology, physiology, nanobiotechnology, and drug discovery. Dr Beckstein has also broad interests in computational method and software development, including the development of novel algorithms to sample and analyze molecular systems. He is a co-founder and core developer of the widely used open source MDAnalysis library for the analysis of biomolecular simulations.

 

Education

  • 2005 DPhil in Biochemistry (University of Oxford, UK)
  • 1999 Diplom (Physik) in Physics, Friedrich-Alexander Universit�t Erlangen-N�rnberg, Germany

 

Research Interests

The focus of the research in the lab is in applying computational methods to understand the molecular mechanisms of biological processes, in particular transport across the cell membrane.

Many proteins in the living cell can be understood as molecular machines that use a source of energy to produce mechanical or chemical work. The lab's primary interest is in those proteins located in the cell membrane that move nutrients, signalling molecules, or waste products into and out of the cell. We study their molecular mechanisms of action by detailed molecular dynamics simulations, which provide a "movie" of full atomic detail of a working protein.Current areas of interest focus on the mechanisms of secondary active transport; methods to accurately simulate macromolecular transitions that are crucial in understanding ligand binding, gating in ion channels, or the translocation of substrates through the cell membrane; and the role of water in confined geometries, for instance in ion channel gating mechanisms or ligand discrimination.

Research Group

See the Beckstein Lab for current members and more about recent activities of the research group.

Research Activity

See the Beckstein Lab web page for recent news.

Courses

Fall 2017
Course Number Course Title
PHY 495 Project Research
NAN 542 Topics in Biophysics
PHY 542 Topics in Biophysics
PHY 792 Research
PHY 799 Dissertation
Summer 2017
Course Number Course Title
PHY 799 Dissertation
Spring 2017
Course Number Course Title
PHY 493 Honors Thesis
PHY 494 Special Topics
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Fall 2016
Course Number Course Title
PHY 495 Project Research
NAN 542 Topics in Biophysics
PHY 542 Topics in Biophysics
PHY 792 Research
PHY 799 Dissertation
Summer 2016
Course Number Course Title
PHY 799 Dissertation
Spring 2016
Course Number Course Title
PHY 493 Honors Thesis
PHY 494 Special Topics
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Fall 2015
Course Number Course Title
PHY 495 Project Research
NAN 542 Topics in Biophysics
PHY 542 Topics in Biophysics
PHY 792 Research
Spring 2015
Course Number Course Title
PHY 315 Quantum Physics II
PHY 493 Honors Thesis
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Fall 2014
Course Number Course Title
PHY 493 Honors Thesis
PHY 495 Project Research
NAN 542 Topics in Biophysics
PHY 542 Topics in Biophysics
PHY 792 Research
Spring 2014
Course Number Course Title
PHY 315 Quantum Physics II
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Fall 2013
Course Number Course Title
NAN 542 Topics in Biophysics
PHY 542 Topics in Biophysics
PHY 792 Research
Spring 2013
Course Number Course Title
PHY 494 Special Topics
PHY 495 Project Research
CHM 598 Special Topics
PHY 598 Special Topics
PHY 792 Research
PHY 799 Dissertation

Presentations

See http://becksteinlab.physics.asu.edu

Editorships

European Biophysics Journal (Advisory Editorial Board)

Professional Associations

<p>Biophysical Society, American Physical Society, American Chemical Society, British Biophysical Society, Deutsche Physikalische Gesellschaft</p>