Robert Ros

Professor
Faculty
TEMPE Campus
Mailcode
1504
Professor
Faculty
TEMPE Campus
Mailcode
1504
Professor
Faculty
TEMPE Campus
Mailcode
1504

Biography

Robert Ros is Professor for Physics and Director of the Center for Biological Physics at Arizona State University. After having completed his undergraduate and graduate studies in physics at the University of Freiburg and Heidelberg, Germany, with the Diplom (comparable to master) and a diploma thesis in the field of biosensor technology at the Applied Physical Chemistry Group of Prof. M. Grunze, he joined the Laboratory for Micro- and Nanotechnology at the Paul Scherrer Institute and the group of Prof. H.-J. Güntherodt, University of Basel, for his PhD. In collaboration with the Biochemistry Group of Prof. A. Plückthun at Zurich University he focused on force spectroscopy experiments on single molecule antibody-antigen complexes and implicating forces with kinetic and thermodynamic parameters. He received a PhD in Experimental Physics in 2000 from the University of Basel, Switzerland. After a postdoc in the lab of Prof. H. Siegenthaler, Department of Chemistry, University of Bern and the Paul Scherrer Institut in the field of electrochemical STM, Dr. Ros moved to the Physics Department at Bielefeld University, where he started as postdoctoral fellow in the Experimental Biophysics and Applied Nanosciences group of Prof. D. Anselmetti. In 2001, he was appointed as Scientific Lecturer (‘Wissenschaftlicher Assistent’, C1) and project leader, and received his Habilitation and venia legendi in Experimental Physics from the Physics Faculty, University of Bielefeld in 2004. After the habilitation he held the position of a University Lecturer ('Hochschuldozent', C2) at the Physics Faculty, Bielefeld University, Germany. In 2008, Dr. Ros joined Arizona State University, where he holds his current appointment.

Dr. Ros is an experimental biophysicist in the field of nanobiophysics with special emphasis on structural biology, physics of molecular recognition, conformational dynamics of single (bio-)molecules, cell adhesion and mechanics using scanning probe methods, force spectroscopy technologies, fluorescence microscopy, and nanophotonics.

Education

  • University of Basel, for his PhD
  • University of Freiburg and Heidelberg, Germany

 

Publications

 

  • B. Plochberger, C. Roehrl, J. Preiner Ch. Rankl, M.  Brameshuber, J. Madl, R. Bittman, R. Ros, P. Hinterdorfer, H. Stangl, G.J. Schuetz; HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study, Scientific Reports (accepted).
  • J.J. Faust, W. Christenson, K. Doudrick, J. Heddleston, T.-L. Chew, M. Lampe, A. Balibayev, R. Ros, T.P. Ugarova; Fabricating Optical-quality Glass Surfaces to Study Macrophage Fusion, JoVE (accepted)
  • I. Gregor, M. Spiecker, R. Petrovsky, J. Großhans, R. Ros, and J. Enderlein; Rapid Non‐linear Image Scanning Microscopy, Nature Methods 14, 1087–1089 (2017). 
  • D.R.-B. Aroush, A. Asnacios, W.-C. Chen, M.E. Dokukin, B.L. Doss, P. Durand, A. Ekpenyong, J. Guck, N.V. Guz, P.A. Janmey, N.M. Moore, A. Ott, Y.-C. Poh, R. Ros, M. Sander, I. Sokolov, J.R. Staunton, N. Wang, D. Wirtz, P.-H. Wu; Comparative study of cell mechanics methods, Nature Methods (accepted).
  • J.J Faust,  W. Christenson; K. Doudrick, R. Ros, and T.P. Ugarova; Fabricating glass surfaces that enable direct visualization of multinucleated giant cell formation Biomaterials 128,  160-171 (2017).
  • A. Navaei, H. Saini, W. Christenson, R.T. Sullivan, R. Ros, and M. Nikkhah; Gold Nanorod-Gold nanorod-incorporated Gelatin-based Conductive Hydrogels for Engineering Cardiac Tissue Constructs, Acta Biomaterialia 41, 133-146 (2016).
  • N. Peela, F.S. Sam; W. Christenson, D. Truong, A.W. Watson, G. Mouneimne, R. Ros, and M. Nikkhah; A Three Dimensional Micropatterned Tumor Model for Breast Cancer Cell Migration Studies, Biomaterials 81, 72-83 (2016).
  • J. Staunton, B. Doss, S. Lindsay, R. Ros; Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices, Scientific Reports 6:19686 (2016).
  • R. Safiullin, W. Christenson, H. Owaynat, I.S. Yermolenko, M.K. Kadirov, R. Ros and T. P. Ugarova; Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating, Biomaterials 67,  151-159 (2015). 
  • S. Bhattacharya, T.-C. Chao, N. Ariyasinghe, Y. Ruiz, D. Lake, R. Ros, A. Ros; Selective trapping of single mammalian breast cancer cells by insulator-based dielectrophoresis, Anal. Bioanal. Chem. 406, 1855-1865 (2014).
  • W. Christenson, I. Yermolenko, B. Plochberger, F. Camacho-Alanis, A. Ros, T.P. Ugarova, and R. Ros. Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices. Ultramicroscopy (2014).
  • O. Schulz, Z. Zhao, A. Ward, M. Koenig, F. Koberling,Y. Liu, J. Enderlein, H. Yan, and R. Ros. Tip induced fluorescence quenching for nanometer optical and topographical resolution. Optical Nanoscopy (2013).
  • The PS-OC Cell-Line Project Team and the PS-OC Network. A physical sciences network characterization of nonmalignant and metastatic cells. Scientific Reports (2013).
  • A. Fuhrmann, S. Getfert, Q. Fu, P. Reimann, S. Lindsay, and R. Ros. Long lifetime of hydrogen-bonded DNA basepairs by force spectroscopy. Biophysical Journal (2012).
  • I. Ashur, O. Schulz, C. McIntosh, I. Pinkas, R. Ros, A.K. Jones. Transparent gold as a platform for adsorbed protein spectroelectrochemistry: investigation of cytochrome c and azurin. Langmuir (2012).
  • I.S. Yermolenko, O.V. Gorkun, A. Fuhrmann, V.K. Lishko, S.P. Oshkadyerov, S.T. Lord, R. Ros, and T.P. Ugarova. The assembly of nonadhesive fibrinogen matrices depends on the alphaC regions of the fibrinogen molecule. J. Biol. Chem (2012).
  • M.-H. Lee , P.-H. Wu , J. Staunton , R. Ros , G. Longmore, D. Wirtz. Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer. Biophysical Journal (2012).
  • B.L. Doss, J.R. Staunton, M. Dannemeyer, M. Linhart, and R. Ros. Combined AFM nanoindentation and finite element analysis of soft heterogeneous biomaterials. Microsc. Microanal (2012).
  • O. Schulz, Z. Zhao, A. Ward, Y. Liu, H. Yan, and R. Ros. Simultaneous atomic force and confocal Fluorescence microscopy for correlated nanometer topographical and optical resolution. Microsc. Microanal (2012).
  • A. Fuhrmann, J. R. Staunton, V. Nandakumar, N. Banyai, P. Davies, and R. Ros. AFM stiffness nanotomography of normal, metaplastic and dysplastic human esophageal cells. Physical Biology (2011).
  • P. Kaur, Q. Fu, A. Fuhrmann, R. Ros, L. Obenauer Kutner, L.A. Schneeweis, R. Navoa, K. Steger, L. Xie, Ch. Yonan, R. Abraham, M.J. Grace, and S. Lindsay. Antibody-unfolding and metastable-state binding in force spectroscopy and recognition imaging. Biophysical Journal (2011).
  • S.K. Lower, S. Lamlertthon, N.N. Casillas-Ituarte, R.D. Lins, R. Yongsunthon, E.S. Taylor, A.C. DiBartola, C. Edmonson, L.M. McIntyre, L.B. Reller, Y.-A. Quee, R. Ros, B.H. Lower, and V.G. Fowler. Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices. Proc. Natl. Acad. Sci. USA (2011).
  • R. Ros. Mechanics and Interactions in DNA and RNA. Molecular Manipulation with Atomic Force Microscopy (2011).
  • I. Yermolenko, A. Fuhrmann, S. Magonov, V. Lishko, S. Oshkadyerov, R. Ros, and T. Ugarova. Origin of the Nonadhesive Properties of Fibrinogen Matrices Probed by Force Spectroscopy. Langmuir (2010).
  • N.P. Podolnikova, I.S. Yermolenko, A. Fuhrmann, V.K. Lishko, S. Magonov, B. Bowen, J. Enderlein, A.V. Podolnikov, R. Ros and, T.P. Ugarova. Control of integrin aIIbß3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry (2010).
  • S. Huang, J. He, S. Chang, P. Zhang, F. Liang, S. Li, M. Tuchband, A. Fuhrmann, R. Ros, and S. Lindsay. Identifying single bases in a DNA oligomer with electron tunnelling. Nature Nanotechnology (2010).
  • Z. Deng, O. Schulz, S. Lin, B. Ding, X. Liu, X. Wei, R. Ros, H. Yan, and Y. Liu. Aqueous Synthesis of Zinc-Blende CdTe/CdS Magic-Core/Thick-Shell Tetrahedral Shaped Nanocrystals with Near-Infrared Emission. J. Am. Chem. Soc (2010).
  • O. Schulz, F. Koberling, D. Walters, M. Koenig, J. Viani, R. Ros. Simultaneous single molecule atomic force and fluorescence lifetime imaging. Proc. of SPIE (2010).
  • A. Fuhrmann and R. Ros. Single molecule force spectroscopy: a method for quantitative analysis of ligand-receptor interactions. (2010).
  • A. Fuhrmann, J.C. Schoening, D. Anselmetti, D. Staiger, and R. Ros. Quantitative analysis of single molecule RNA-protein interaction. Biophysical Journal (2009).
  • K. Wollschläger, K. Gaus, A. Körnig, R. Eckel, S.D. Wilking, M. McIntosh, Z. Majer, A. Becker, R. Ros, D. Anselmetti, N. Sewald. Single-Molecule Experiments to Elucidate the Minimal Requirement for DNA Recognition by Transcription Factor Epitopes. Small (2009).
  • R. Ros and N. Hansmeier. Gene Classification and Quantitative Analysis of Gene Regulation in Bacteria using Single Cell Atomic Force Microscopy and Single Molecule Force Spectroscopy, in Single Cell Analysis. Single Cell Analysis (2009).
  • A. Fuhrmann, S. Getfert, D. Anselmetti, P. Reimann, and R. Ros;. Refined procedure of evaluating experimental single-molecule force spectroscopy data. Phys. Rev. E (2008).
  • D. Anselmetti, F.W. Bartels, A. Becker, B. Decker, R. Eckel, M. McIntosh, J. Mattay, P. Plattner, R. Ros, Ch. Schäfer, and N. Sewald;. Reverse Engineering of an Affinity-Switchable Molecular Interaction Characterized by AFM Single Molecule Force Spectroscopy. Langmuir (2008).

Research Activity

Courses

Fall 2017
Course Number Course Title
PHY 111 General Physics
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Summer 2017
Course Number Course Title
BIO 495 Undergraduate Research
PHY 792 Research
PHY 799 Dissertation
Spring 2017
Course Number Course Title
PHY 111 General Physics
PHY 493 Honors Thesis
PHY 495 Project Research
PHY 792 Research
PHY 799 Dissertation
Fall 2016
Course Number Course Title
PHY 111 General Physics
PHY 472 Advanced Biophysics Lab
PHY 792 Research
PHY 799 Dissertation
Summer 2016
Course Number Course Title
BIO 495 Undergraduate Research
PHY 792 Research
PHY 799 Dissertation
Spring 2016
Course Number Course Title
PHY 493 Honors Thesis
PHY 792 Research
PHY 799 Dissertation
Fall 2015
Course Number Course Title
PHY 472 Advanced Biophysics Lab
PHY 792 Research
PHY 799 Dissertation
Summer 2015
Course Number Course Title
BIO 495 Undergraduate Research
PHY 792 Research
Spring 2015
Course Number Course Title
PHY 111 General Physics
PHY 493 Honors Thesis
PHY 792 Research
PHY 799 Dissertation
Fall 2014
Course Number Course Title
PHY 472 Advanced Biophysics Lab
PHY 792 Research
PHY 799 Dissertation
Summer 2014
Course Number Course Title
BIO 495 Undergraduate Research
PHY 792 Research
Spring 2014
Course Number Course Title
PHY 472 Advanced Biophysics Lab
PHY 493 Honors Thesis
PHY 792 Research
PHY 799 Dissertation
Fall 2013
Course Number Course Title
PHY 792 Research
PHY 799 Dissertation
Spring 2013
Course Number Course Title
PHY 111 General Physics
PHY 493 Honors Thesis
PHY 792 Research
PHY 799 Dissertation

Editorships

Ultramicroscopy, Assoc. Editor (2011-2016)

Professional Associations

<p>Member, German Physical Society Member, Biophysical Society (USA) Member, American Physical Society Member, American Chemical Society Member, German Association of University Professors and Lecturers</p>

Service

  • Center for Biological Physics, Director (since 2012)
  • CLAS Research Advisory Committee, Member (2014-2016)
  • Undergraduate Committee, Member (2012 - 2015)
  • Undergraduate Biophysics (BS) program, Director (2012 - 2015)
  •  
  • MRS Symposium "Frontiers in Scanning Probe Microscopy", MRS Fall Meeting 2015., Organizer 
  • 6th AFMBioMed Conference, San Diego, Session Organizer and Chair (2014)
  • NanoEngineering for Medicine and Biology (NEMB2013), Organizer and Session Chair of Track 6 "Biological Nanomechanics: Materials Factors in Physiology, Disease and Treatment" (2014)