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Uwe Weierstall's research focuses on developing methods for structure determination of biomolecules with X-ray free electron laser (XFEL) sources. These X-ray sources produce very high intensity pulses of X-rays - compared to a regular 3rd generation synchrotron, the number of photons/second is larger by a factor of 10 billion and concentrated into a few femtoseconds. This increase in intensity allows structure determination from much smaller protein crystallites then the ones used in conventional protein crystallography and may even allow single particle structure analysis at high resolution from identical particles (e.g. viruses) where crystals cannot be grown. Professor Weierstall has been involved in XFEL science and the development of liquid jet sample delivery systems since the first XFEL experiments in 2008 at the Linac Coherent Light Source (LCLS).
Serial Femtosecond crystallography, Single particle Imaging, Electron- and X-ray Diffraction, Scientific Instrument Design,
See: https://scholar.google.com/citations?hl=en&user=VbnK3ccAAAAJ&view_op=list_works&sortby=pubdate
Patents (pending and granted):
Apparatus and methods for a gas dynamic virtual nozzle
Patent number: 9289787
Apparatus and Methods for Lipidic Cubic Phase (LCP) Injection for Membrane Protein Investigations
Publication number: 20160051995
Gas dynamic virtual nozzle for generation of microscopic droplet streams
Patent number: 8272576
SYSTEM AND METHOD FOR PROVIDING A MICRON-SCALE CONTINUOUS LIQUID JET
Publication number: 20140263693
Methods and Devices for Rapidly Forming Vitreous Ice-Jacketed Particle Droplets
Publication number: 20080283775
Methods and devices for molecular structure determination
Publication number: 20060262317
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